NEWYou can now listen to Fox News articles!
Puzzling cancer and Alzheimer's link explored in new study: 'SHORT QUOTE'
A new study may help clarify a long-observed link between cancer history and reduced Alzheimer’s risk.
The research, published in the journal Cell, used mouse models to explore how the biological changes associated with cancer may affect the progression of the most common dementia type.
The findings suggest that certain cancers release a protein called cystatin-C that can travel through the bloodstream and enter the brain, an area that many Alzheimer’s treatments have difficulty reaching.
ALZHEIMER’S RISK TIED TO HOW THE BODY HANDLES SUGAR AFTER EATING, STUDY FINDS
Cystatin-C binds to harmful amyloid protein clumps linked to Alzheimer’s and activates a protein called TREM2, which acts like an on-switch for the brain’s immune cells.
When activated, those cells begin clearing away existing amyloid plaques, a process that was associated with reduced plaque buildup and improved cognitive function, the study found.
New research suggests that cancer-related biological changes may help explain why a history of cancer is linked to lower Alzheimer’s risk. (iStock)
Dr. Bob Arnot, a Vermont-based internal medicine physician, told Fox News Digital that the findings help clarify a pattern doctors have observed for years.
CLICK HERE TO SIGN UP FOR OUR LIFESTYLE NEWSLETTER
"Scientists have long observed a puzzling statistical pattern known as ‘inverse comorbidity’ — people with a history of cancer are less likely to develop Alzheimer’s disease, and people with Alzheimer’s are less likely to develop cancer," said Arnot, who was not involved in the study.
Cystatin-C sticks to harmful amyloid clumps and turns on brain immune cells, helping them clear plaques and improve brain function. (iStock)
The findings suggest that biological signals tied to certain cancers may slow or reverse key features of Alzheimer’s disease.
CLICK HERE FOR MORE LIFESTYLE STORIES
Arnot said the research is notable because it identifies a specific biological pathway that could be targeted for future Alzheimer’s treatments.
"This approach targets existing amyloid plaques, not just early prevention. That distinction could be critical for patients who already have established disease," he said.
The results suggest that cancer-related biological signals may help slow or even reverse some core aspects of Alzheimer’s disease. (iStock)
Arnot cautioned that the findings do not mean cancer itself is protective.
"This study does not suggest that cancer is protective, desirable or a viable therapy," he said. "Instead, it reveals that biological programs activated during cancer can inadvertently engage protective immune mechanisms in the brain."
TEST YOURSELF WITH OUR LATEST LIFESTYLE QUIZ
The research suggests that future treatments could focus not just on slowing Alzheimer’s, but also on clearing harmful buildup in the brain, Arnot added.
CLICK HERE TO DOWNLOAD THE FOX NEWS APP
The results were based on experiments in animal models, and further research is needed to determine whether the same effects occur in humans, the researchers noted.
Kelly McGreal is a production assistant with the lifestyle team at Fox News Digital.
